![]() ![]() Exercise-induced heat can cause physiological strain as discussed above, according to a 2015 review in Scandinavian Journal of Medicine & Science in Sports (opens in new tab), and can also lead to dehydration through sweat as the body attempts to maintain a consistent and safe temperature.ĭehydration is one of the main contributors to fatigue according to a 2011 paper in the Journal of Sports Sciences (opens in new tab), and sweating can lead to significant losses of essential minerals such as sodium, magnesium and calcium, which can lead to greater muscle fatigue. These effects can hamper cross-bridging and calcium release, and the result of this is decreased muscular force production.Ī huge factor that causes muscles to fatigue is the increase in heat experienced by the body when exercising. Hydrogen Ions induce fatigue by creating a more acidic environment in the muscle.Īccording to research findings published in Sports Medicine (opens in new tab) and Clinical and Experimental Pharmacology and Physiology (opens in new tab), muscular work can cause decreases in ATP and PCr and an accumulation of Hydrogen Ions and Magnesium ions, which inhibit the release of calcium. One of the reasons ATP is so important is that it allows for the release of calcium from within muscle cells to allow contractions to take place, and an important by-product of creating ATP is a build-up of Hydrogen Ions, as shown in Talanta (opens in new tab). Phosphocreatine (PCr for short) is a high-energy chemical that acts as a reserve of phosphates to create more ATP, as illustrated in Muscle Physiology (opens in new tab). A chemical called Adenosine Triphosphate (ATP) is essential to allow this to occur, and can be thought of as muscle currency - the more you have, the more your muscles can work, as outlined in Progress in Biophysics and Molecular Biology (opens in new tab). ![]() At the most fundamental level, muscle contracts by individual fibers (called actin and myosin) sliding over each other, and forming cross-bridges. (Image credit: Getty Images) Causes of muscle fatigueīefore we start discussing what causes muscle fatigue, we first need to understand what allows muscles to contract and work.
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